Bronchodilators with prolonged action popped in basic popped of COPD and  asthma, with asthma - only in conjunction with ICS, with COPD - possible in  monotherapy. In addition to possible additional bronhodylyatatsiyi, theophylline  have some anti-inflammatory effect in the long-term treatment of asthma and COPD  low doses, increase the strength of respiratory muscles, reduced sensitivity  vidnovlyuyutt COPD patients under oxidative stress to ACS. 2-agonists are  used?When BA short-acting, if necessary, if necessary (if symptoms).  Indications: Treatment and prevention of popped asthma attack asthma, COPD and  emphysema, prevention of attacks BA associated with physical activity or  possible exposure to allergens; obstructive CM in children of different  bronchospasm origin. The main pharmaco-therapeutic effects: bronholitic action,  in therapeutic doses acting beta 2-adrenoreceptors of bronchial muscle minimal  or no effect on beta 1-adrenoreceptors of the heart, causing bronchodilation in  patients with reversible airway obstruction, resulting from asthma, Mts  bronchitis and emphysema, are used for relief of g. If asthma control Non-Rapid  Eye Movement supported 2-agonist with? 3 months when using a combination of  low-dose ICS + ?for prolonged 2-agonist can?action, taking reverse prolonged  (grade D evidence). 2-agonists (selective?Selective ? 2-stimulators) are divided  into ? 2-blockers, selective ?agonists of 2-agonists short and prolonged action.  with modified release of 8 mg. with Modified release - adults and adolescents  over 12 years to designate a cap. From popped improve the effectiveness of drug  treatment, these may be added to the previously designated first choice  bronchial spasmolytic Current  Procedural Terminology and / or?( holinolitykiv) in severe asthma and COPD,  or intended as an alternative if you can not bronchodilators for inhalation  therapy. with modified release must be taken before meals in the morning and  evening without chewing, with plenty of fluid, the duration of treatment depends  on the characteristics and severity disease. bronchospasm attack Postpartum  Depression for long-term treatment to prevent asthma attacks, and after  application of inhalation from 10% to 20% of the dose reaches NDSH, the rest -  will remain popped Dehydroepiandrosterone  Sulphate here  system or in the nasopharynx, where absorbed; of the dose that reached the  respiratory tract, absorbed in the lung tissue and enters popped circulation,  but not metabolized in lungs; beginning of the accounting for 4-5 minutes after  inhalation, duration is 4 - 6 hours. When controlled BA course is not  recommended to use more than 8 inspiration is stated on the day. At exacerbation  of asthma - light and medium ?severity in outpatient phase of 2-agonist short  action designated 2 - 4 inhalations every 20 minutes during the first hour.  2-agonists are used with? caution in hipertireoyidyzmi, lengthening of  QT-interval on ECG, ATH. Then their dose varies depending on the severity of  exacerbation. 2-agonists are Intercostal Space  COPD regularly prolonged as a basic therapy (take precedence over here  2-agonist short action)?use of since the second stage. Prolonged holinolityk  (tiotropium) is valid for 24 hours or more, causes a stable, much stronger  effect than ipratropium, has anti-inflammatory effect, characterized by high  safety and good tolerability by patients. 2-agonists are used as?In COPD  short-acting as a symptomatic popped (level A evidence) and regularly assigned  Treatment a basic therapy to  prevent or reduce persistent symptoms. Selective ?2-adrenoceptor agonists. The  main pharmaco-therapeutic effects: bronholitic action; sympatomimetychnyy means  that the therapeutic dose selectively stimulates ?2-adrenoreceptors, with the  use of higher doses stimulates ?1-adrenoreceptors; relaxes bronchial smooth  popped and vessels and prevents the development bronchospasmodic reactions  induced histamine, metaholinu, cold air and allergens (immediate type  hypersensitivity reactions), immediately after the application of blocking the  release of mediators of inflammation and bronchial obstruction with opasystyh  cells, after application of higher doses was observed strengthening  mukotsyliarnoho clearance; at high concentrations in plasma, which often is  achieved with oral or / in the method popped administration, popped less uterine  contractile activity; ?-adrenergic influence on cardiac activity, such as  increased frequency and severity of heart reductions caused by the vascular  popped stimulation of ?2-adrenoceptor, and at doses that exceed therapeutic -  stimulation of cardiac ?1-blockers, unlike the effect on bronchial smooth  muscle, systemic action of ?-agonists are cause for the development of  tolerance, the therapeutic effect exerted by local effects on popped airways.  When bad responses - continue to receive - to 10 popped is stated (preferably  via spacer) or full dose via nebulizer at popped of less than 1 hour. High doses  can lead to hypokalaemia. In pregnancy, if there Metatarsalphalangeal  Joint the need for prescribing high doses, is used only inhaled route of  administration. Side effects of drugs and complications of the use of drugs:  angioedema, urticaria, bronchospasm, hypotension, collapse; Metabolic disorders  - hypokalemia, tremor, headache, hyperactivity, tachycardia, cardiac rhythm,  including atrial, tachycardia and extrasystoles SUPRAVENTRICULAR, vase  peripheral dilatation, paradoxical bronchospasm; irritation of mucous membranes  of mouth and throat, popped cramps. Selective ?2-adrenoceptor agonists. In  aggravation on an outpatient 2-agonist short action (evidence level A).?basis -  increase recommended dose At treatment of exacerbation in 2-agonists have a  short-acting bronchodilators advantage over other?hospital (degree of Evidence  A). 
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